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Journal of Advanced Research 24 (2020)

Colorectal cancer screening: Assessment ofCEACAM6,LGALS4,TSPAN8andCOL1A2as blood markers in faecal immunochemical test negative subjects


By testing the CELTiC panel in 174 FIT negative subjects, we confirmed our previous findings on the efficacy of the proposed blood-based biomarkers as potential candidates to implement the non-invasive screening of CRC. TSPAN8 and LGALS4 could be particularly useful to identify patients affected by high-risk lesions or CRC and possibly to exclude false positive FIT subjects. The low technical variability further confirmed the reliability and the robustness of the protocol. Additional studies are needed to increase the number of FIT positive subjects to better discriminate false positive FIT from patients affected by low risk lesions.

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